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Our laboratory demonstrated that SERT and αvβthree receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβthree in midbrain synapses. Earlier studies suggest that in platelets, the Affiliation of SERT with activated αIIbβ3 integrins, and its localization to adhesion complexes, are correlated with improved uptake activity (Carneiro et al.
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